Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,076 – 3,090 of 3,769 results

3,076

Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg

SKF38393 HCl is a selective dopamine D1 receptor agonist exhibiting activity through direct binding and stimulation of D1 receptors Activation of D1 receptors primarily induces adenylyl cyclase stimulation and increases cAMP-dependent protein kinase signaling subsequently modulating neuronal differentiation growth and dopamine-mediated functional responses Experimental evidence indicates that SKF38393 administration impacts gene expression patterns related to dopamine receptor-sensitive neuronal pathways and neuropeptides Additionally in vitro studies report SKF38393 to inhibit proliferation of certain tumor cell lines exemplified by decreased cell growth in breast carcinoma-derived MCF-7 cells at submicromolar concentrations It is widely utilized as a pharmacological tool in neuroscience and oncology research

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3,077

Apexbio Technology LLC CUDC-907 1339928-25-4 200mg

CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research

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3,078

Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG

ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only.

Inhibits human, dog, rat, mouse, guinea pig, macaque CXCR7 with IC50s of 3.2, 2.3, 3.1, 2.3, 0.6, 1.5 nM respectively.
Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
Increases plasma CXCL12 concentration in naive male DBA/1 mice.
Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) model.
Increases myelination in the Cuprizone-induced demyelination model mice.